“Should I use my new NVMe or old SATA SSD for booting Windows 10?”

The general rule is: Put the operating system, and your other most-frequently-accessed files, on the fastest drive.

NVMe drives can be faster than classic SATA drives; but the fastest SATA SSDs are faster than some run-of-the-mill NVMe SSDs. Plus, some of the spec-sheet advantages of NVMe may not matter all that much under real-world conditions. (See articles listed at the end of this text.)

So, I suggest you run some benchmark tests on your drives to see which is really faster. (Benchmarks aren’t always right, but they give you something to go on.) There are many disk benchmarks to choose from, including CrystalDiskMark, PassMark, and others.

If your NVMe drive really is faster, and if it’s large enough to hold a normal Win10 setup (ideally, including the required pagefile and optional hibernation files), then make that the boot drive.

If space if tight, you can relocate the pagefile to the SATA SSD —- even a “slow” SSD is plenty fast for normal pagefile operation, especially if your PC has sufficient RAM.

More:

NVMe vs SATA:What’s the difference and which is faster?

NVMe vs. M.2 vs. SATA – What’s the Difference? – Custom Gaming & Enthusiast PC Blog | Velocity Micro

SATA vs. NVMe: Should You Upgrade Your SSD System Drive? – ExtremeTech

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